If a dog takes isoniazid, how long will it take for the drug to start taking effect?

Jul 26,2025
3Min
If a dog eats isoniazid, how long will it take for the drug to take effect? ​​For dogs, isoniazid is very deadly. Feed isoniazid at a dose of 150 mg/kg. After isoniazid enters the dog's body, it reaches the plasma in about 30 minutes. At the peak of the value, it can cause myocardial necrosis in dogs and cause severe metabolic acidosis. Under normal circumstances, the cure rate is only 10%.

Published in "Sichuan Animal Husbandry and Veterinary Medicine" in 2015, a paper titled "Feasibility Study on Isoniazid to Extinguish Stray Dogs" introduced that 15 dogs were divided into three groups, with doses of 50mg/kg and 100mg/kg. kg, 150 mg/kg, different doses of isoniazid were fed to dogs. Most of the dogs that were successfully administered the drug were poisoned and died, which only took 90 minutes.

Cui Tingting, the author of the paper, said that the experiment was conducted just to find an effective way to cull stray dogs in rabies-affected areas. She said that the experiment was limited to the laboratory and was not promoted to the society. She asked the general public not to abuse drugs.

Isoniazid is an anti-tuberculosis drug and is a prescription drug. This drug is mostly used to treat Mycobacterium tuberculosis. It is a prescription drug and cannot be purchased in pharmacies. It is not harmless to people without tuberculosis. If normal people consume isoniazid, they will develop peripheral neuritis, which is manifested as numbness of the limbs, slow reaction, ataxia, muscle atrophy in severe cases, and life-threatening conditions in severe cases.

In the list of carcinogens published by the World Health Organization's International Agency for Research on Cancer, isoniazid belongs to Category 3 carcinogens (its carcinogenicity to humans cannot yet be classified, that is, it is suspected to be carcinogenic to humans).

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