Do dog vaccines have to be given 21 days apart?

Dog vaccines need to be vaccinated within 21 days. The time can be advanced appropriately, but it cannot be exceeded. Once the 21 days are exceeded, the vaccine injected in between will become invalid and need to be re-vaccinated. Therefore, when vaccinating your dog, you need to remember the time and complete the injection within the specified time so that effective antibodies can be formed in the dog's body.
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