Contents

① The adverse reactions and hazards of amoxicillin overdose, and examples of common pet drugs ② The adverse reactions and hazards of gentamicin overdose, and examples of common pet drugs ③ The adverse reactions and hazards of doxycycline overdose Hazards, and examples of common pet drugs ④ Adverse reactions, hazards of oxytetracycline overdose, and examples of common pet drugs ⑥ Contraindications of other antibiotics ⑦ How to prevent overdose of antibiotics

Adverse effects of overdose of amoxicillin Reactions, hazards, and examples of common pet drugs

Attribution:

Penicillin antibiotics, do not use if you are allergic

Adverse reactions:

① Nausea, vomiting , diarrhea, pseudomembranous colitis and other gastrointestinal reactions.

② Allergic reactions such as rash, drug fever and asthma.

③ Anemia, thrombocytopenia, eosinophilia, etc.

④ Serum aminotransferase may be slightly increased.

⑤ Superinfection caused by Candida or drug-resistant bacteria.

⑥ Central nervous system symptoms such as excitement, anxiety, insomnia, dizziness and abnormal behavior are occasionally seen.

Hazards of oral overdose of amoxicillin:

Acute renal failure, hematuria.

Case:

"Acute Renal Failure Caused by Amoxicillin Overdose", Journal of Adverse Drug Reactions, Issue 04, 2010

"Review of Medical Literature on Kidney Damage Caused by Amoxicillin", Journal of Adverse Drug Reactions, Issue 04, 2008

"Amoxicillin capsules cause severe angioedema", Anti-infectious Pharmacy, 2009.6

Examples of common pet drugs:

Pfizer Sono (imported), Ainata amoxicillin tablets (domestic)

Adverse reactions and hazards of gentamicin overdose , and examples of common pet drugs

Affiliation:

Aminoglycoside antibiotics, do not use if you are allergic.

Adverse reactions:

① Rare gastrointestinal symptoms such as nausea, loss of appetite, vomiting, abdominal distension, rash, and elevated serum aminotransferase;

② Symptoms of ototoxicity and nephrotoxicity are occasionally seen.

Hazards of gentamicin overdose:

① Impairment of vestibular function (ototoxicity/deafness), hearing loss

② Damage to kidney function, hematuria, significant reduction in urination frequency or urine output, extreme thirst (nephrotoxicity)

Case:

"The effect and mechanism of Shenqi Pills on Notch2/hes1 signaling pathway in gentamicin-induced rat ear and kidney injury model", Hubei University of Traditional Chinese Medicine, 2013

"The inhibitory effect and mechanism of gentamicin on the peripheral cholinergic efferent nervous system signal transduction pathway in the vestibule of guinea pigs", Huazhong University of Science and Technology, 2014

"QingdaComparative study on early biomarkers of nephrotoxicity caused by ampicillin and netilmicin", Chinese Journal of Antibiotics, Issue 04, 2014

Examples of common pet drugs:

Pelixin Gentamicin Sulfate Injection

Adverse reactions and hazards of doxycycline overdose, and examples of common pet drugs

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Also known as: doxycycline hydrochloride

Classification:

Tetracycline, allergic and contraindicated

Adverse reactions:

① Nausea , vomiting, abdominal pain, diarrhea and other gastrointestinal reactions;

② Liver toxicity and occasionally pancreatitis may occur;

③ Allergic reactions, mostly rashes, occasionally anaphylactic shock and asthma;

④ Occasionally it can cause hemolytic anemia, thrombocytopenia, neutropenia or eosinophilia;

⑤ Affects the central nervous system, and can occasionally cause benign intracranial pressure increase, which can manifest as headache, vomiting, papilledema, etc., which can be relieved after stopping the drug;

⑥ Superinfection with drug-resistant Staphylococcus aureus. Gram-negative bacteria and fungi cause infections of the digestive tract, respiratory tract and urinary tract, and in severe cases can cause sepsis.

⑦ The normal flora in the body is reduced, leading to vitamin deficiency, fungal reproduction, dry mouth, pharyngitis, angular stomatitis and glossitis, etc.

Dangers of overdose of doxycycline:

① can cause severe liver damage;

② Occasionally fatal renal poisoning

There is controversy about the nephrotoxicity of doxycycline:

Statement 1: Xicycline is nephrotoxic, but doxycycline is not very nephrotoxic and is occasionally used in cases of renal failure; Statement 2: Occasionally See fatal nephrotoxicity, this term comes from the drug instructions.

Case:

"A Case of Acute Liver Damage Caused by Doxycycline Tablets", Anti-Infectious Pharmacy, 2015.12 "Two Cases of Liver Damage Caused by Doxycycline and Azithromycin", Chinese Journal of Hospital Pharmacy, 2004 Issue 07

Examples of common pet drugs:

Yulixian Doxycycline Hydrochloride Tablets

Adverse reactions and hazards of overdose of oxytetracycline, and examples of common pet drugs

Attribution:

Tetracyclines, do not use if allergic to

Doxycycline is an evolved version (new generation) of sicyclines. It turns out that doxycycline is an evolved version of oxytetracycline?

Adverse reactions:

① Digestive system: Gastrointestinal symptoms such as nausea, vomiting, epigastric discomfort, abdominal distension, diarrhea, and occasional reports of pancreatitis, esophagitis and esophageal ulcer

② Hepatotoxicity: usually fatty liver degeneration

③ Allergic reaction: mostly rash, occasionally anaphylactic shock and asthma

④ Blood system: Occasionally it can cause hemolytic anemia, thrombocytopenia, neutropenia and eosinophilia.

⑤ Central nervous system: Occasionally, it can cause benign intracranial pressure increase, which can manifest as headache, vomiting, papilledema, etc.

⑥ Nephrotoxicity: Patients with original significant renal impairment may develop aggravation of azotemia, hyperphosphatemia and acidosis.

⑦ Superinfection: Long-term use of this product may cause digestive tract, respiratory tract and urinary tract infections caused by drug-resistant Staphylococcus aureus, Gram-negative bacilli and fungi, and in severe cases may cause sepsis.

⑧ This product can be deposited in teeth and bones, causing varying degrees of discoloration and yellowing of teeth, enamel dysplasia and caries, and can cause skeletal dysplasia.

⑨ The application of this product can reduce the normal flora in the human body, leading to vitamin B deficiency, fungal reproduction, dry mouth, sore throat, angular stomatitis and glossitis, etc.

Hazards of overdose of oxytetracycline:

① The above adverse reactions may occur

② Liver damage, hepatocyte necrosis, jaundice, hepatic steatosis

③ Kidney failure

Case:

"Report on Diagnosis and Treatment of Oral Oral Oxytetracycline Poisoning in Animals", Modern Agriculture, Issue 01, 2009

"Diagnosis and Treatment of Oxytetracycline Poisoning in Snow Mastiffs", Chinese Veterinary Medicine, Issue 07, 2014

Examples of common pet drugs:

Otetracycline is generally for veterinary use. Due to its side effects, it is difficult to see it in pet drugs, so use it with caution.