Experts have done a lot of research, and the results prove that vaccination is indeed a good way to prevent infectious diseases in dogs. However, the protection rate of the vaccine is 90%-95%, which is not 100% absolute safety. Dog vaccines also have the problem of failure, and there are many factors that affect the effectiveness of the vaccine, such as the following factors:

Insufficient antibodies lead to vaccine failure

Whether the vaccine can prevent diseases after injection depends on whether the vaccine can stimulate the dog to produce antibodies and the amount of antibodies (expressed by titer).

It is generally believed that infectious diseases can be prevented only when the serum antibody titer is greater than 10 international units per milliliter. About 30% of dogs develop antibodies one month after the vaccine is injected, and the antibodies reach the highest level one month after the full course of injection is completed. Therefore, if the antibody is not produced or the titer is relatively low before all injections are completed, there is still the possibility of contracting the disease. During this time, dogs must still receive other close precautions.

Poor health can lead to vaccine failure

We know that sick dogs cannot be vaccinated. For example, if the parasites are not removed and you have a high fever, vaccination will cause immune disorders.

Vaccine failure caused by virus infection

Dog vaccines are generally vaccinated before a comprehensive physical examination. Although the indicators are normal, the disease may still be in the incubation period and cannot be detected. The antibodies produced by the vaccine are only effective against viruses in the blood and not against viruses that enter cells. Therefore, if the vaccine is already infected with the virus before injection, the injection will not be effective.

Virus mutation causes vaccine failure

Even if the vaccine injection produces high-titer antibodies, a small number of dogs may still get sick. This is because viruses can mutate, and existing vaccines target normal viruses. If the surface antigen of the virus mutates, and the vaccinated dog is unfortunately infected with this mutated virus, it is still possible to get sick.

Improper vaccine injection leads to vaccine failure

Many doctors will inject dogs into the buttocks, but the vaccine should not be injected into the buttocks. Because there is a lot of fat tissue in the buttocks and few immune active cells, the antibody titers produced after injection are low and the antibodies decline quickly.

Vaccine failure due to incorrect timing of vaccination

Most of the time it is too early. When antibodies are injected multiple times, some of the antigens are eliminated. Of course, the functionality that can be produced is significantly reduced. Or if you don't follow the doctor's instructions for boosting for more than a year, there will be no increase. Of course, there is also the possibility of infection, because the effect of the vaccine can only last for one year.

Improper storage of vaccines leads to vaccine failure

Vaccines have their own safe storage methods. They should not be stored in an environment of 37 degrees Celsius for more than one month, and should not be stored in an environment of 4 degrees Celsius for more than one year. And vaccines should not be frozen, as freezing can damage their structure. At the same time, if the vaccine is stored for too long, the immune effect will be reduced. Generally, vaccines can be stored in the refrigerator compartment of a household refrigerator..

PS: Due to the imperfect immune system of some dogs, the injected vaccines will also be ineffective.