Insufficient antibodies lead to vaccine failure

Whether the vaccine can prevent diseases after injection depends on whether the vaccine can stimulate the dog to produce antibodies and the amount of antibodies (expressed by titer).

It is generally believed that only when the serum antibody titer is greater than 10 international units per milliliter, infectious diseases can be prevented. Antibodies appear in about 30% of dog vaccines one month after injection, and reach their highest levels throughout the month after injection. Therefore, when antibodies are not produced or have low titers before full injection, the possibility of infection still exists. During this time, dogs still require other close precautions.

Poor health

We know that sick dogs cannot be vaccinated. For example, if the parasites are not removed and you have a high fever, vaccination will cause immune disorders.

Already infected with the virus

Before injecting the dog with a vaccine, a comprehensive physical examination is generally required. Although all indicators are normal, it may still be due to the incubation period of the disease. Can't check it out. The antibodies produced by the vaccine are only effective against viruses in the blood and are ineffective against viruses that have already entered cells. Therefore, if you have been infected with the virus before the vaccine is administered, the vaccine will be ineffective.

Mutation of the virus

Even if the vaccine produces high titers of antibodies, a small number of dogs may still get sick. This is because viruses can mutate, and existing vaccines target normal viruses. If the surface antigen of the virus mutates, and the vaccinated dog is unfortunately infected with this mutated virus, it is still possible to get sick.

Improper vaccination

Many doctors inject dogs into the buttocks, and it is not recommended to inject vaccines into the buttocks. Since there is a lot of fat tissue in the buttocks and few immune active cells, the antibody titer is low and the antibodies drop rapidly after injection.

The timing of the dog vaccine injection is wrong

Mostly it is too early. When the transitional antibodies are still abundant, part of the antigen will be offset and the function will be greatly reduced. Or if you fail to follow the doctor's instructions and do not take additional doses for more than a year, of course you may still be infected, because the vaccine effect can only last for one year.

Improper storage of vaccines will lead to failure

Vaccines have their own safe storage methods. They should not be stored at 37 degrees Celsius for more than one month, and should not be stored at 4 degrees Celsius for more than one year. And vaccines should not be frozen, as freezing can damage their structure. At the same time, if the vaccine is stored for too long, the immune effect will be reduced. Generally, vaccines can be stored in the freezer of a household refrigerator.